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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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The aim of the study is to investigate the significance of intact nerve supply to the liver for the glucagon-like peptide-1 (GLP-1) induced insulin secretion.
The hypothesis is that the effects of GLP-1 is transmitted through the GLP-1 receptor and that these effects involve sensory afferent neurons, probably primarily parasympathetic.
GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis that GLP-1 interact locally with afferent sensory nerve fibers.
The aim of this study is to investigate the significance of intact liver innervation for the GLP-1 induced insulin secretion in liver transplanted patients; kidney transplanted control patients matched for immunosuppressive treatment, age, gender and body weight; and ten control persons matched for age, gender and body weight.
The insulin secretion will be evaluated from blood samples that will be analyzed for insulin and c-peptide.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liver transplanted | Experimental | 10 Liver transplanted patients |
|
| Kidney transplanted | Experimental | 10 kidney transplanted individuals |
|
| Healthy controls | Experimental | 10 healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dipeptidyl peptidase 4 (DPP4) inhibitor | Drug | One tablet (50 mg)of DPP4 inhibitor is to be taken 12 and 1 hours before start of the oral glucose tolerance test (50 g glucose and 1.5 g paracetamol dissolved in 300 ml water)on day 3 |
| Measure | Description | Time Frame |
|---|---|---|
| insulin secretion | The insulin secretion during a four-hour oral glucose tolerance test (OGTT) and an intravenous isoglycaemic clamp is evaluated | four hours |
| Measure | Description | Time Frame |
|---|---|---|
| plasma glucose | 20 blood samples will be drawn during the four hours OGTT and intravenous isoglycaemic clamp, most frequently during the first hour | 20 time points within four hours |
| plasma GLP-1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Astrid Plamboeck, M.D. | Contact | +45 26208174 | astridp@sund.ku.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Internal Medicine F' laboratory | Recruiting | Hellerup | Copenhagen | 2900 | Denmark |
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| ID | Term |
|---|---|
| D018819 | Dipeptidyl Peptidase 4 |
| D000077597 | Vildagliptin |
| D005947 | Glucose |
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D004152 | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases |
| D020689 | Exopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
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|
| oral glucose | Other | 50 grams glucose dissolved in 300 ml water with 1.5 grams paracetamol |
|
|
| intravenous glucose | Other | 1.5 g paracetamol dissolved in 50 ml water is to be ingested orally within the first 2 minutes. Intravenous glucose is supplied in an amount to match the plasma glucose during the oral glucose tolerance test |
|
|
12 blood samples will be drawn during the four hours OGTT and intravenous isoglycaemic clamp, most frequently during the first hour
| 12 time points within four hours |
| plasma GIP | 12 blood samples will be drawn during the four hours OGTT and intravenous isoglycaemic clamp, most frequently during the first hour | 12 time points within four hours |
| plasma glucagon | 12 blood samples will be drawn during the four hours OGTT and intravenous isoglycaemic clamp, most frequently during the first hour | 12 time points within four hours |
| plasma GLP-2 | 12 blood samples will be drawn during the four hours OGTT and intravenous isoglycaemic clamp, most frequently during the first hour. | 12 time points within four hours |
| plasma PYY | 12 blood samples will be drawn during the four hours OGTT and intravenous isoglycaemic clamp, most frequently during the first hour | 12 time points within four hours |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D057057 | Serine Proteases |
| D000945 | Antigens, Differentiation, T-Lymphocyte |
| D000943 | Antigens, Differentiation |
| D000954 | Antigens, Surface |
| D000941 | Antigens |
| D001685 | Biological Factors |
| D015415 | Biomarkers |
| D009570 | Nitriles |
| D009930 | Organic Chemicals |
| D011759 | Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |