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The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ONSERAN | Experimental |
| |
| NASEA | Experimental |
| |
| ALOXI | Experimental |
| |
| normal saline | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ondansetron | Drug | Ondansetron/single injection/4 mg/IV |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| severity of nausea | during 73 hours after surgery | |
| the number of vomiting | during 73 hours after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance Hospital, Yonsei University College of Medicine | Seoul | 120-752 | South Korea |
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| Ramosetron | Drug | Ramosetron HCl/single injection/0.3mg/IV |
|
|
| Palonosetron | Drug | Palonosetron HCl/single injection/0.075mg/IV |
|
|
| Normal saline inj | Drug | normal saline injection 2ml |
|
| ID | Term |
|---|---|
| D017294 | Ondansetron |
| C071315 | ramosetron |
| D000077924 | Palonosetron |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D002227 | Carbazoles |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D011812 | Quinuclidines |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D007546 | Isoquinolines |
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