Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

Prophylactic Effects of Ondansetron, Ramosetron, and Palonosetron on Patient-Controlled Analgesia Related Nausea and Vomiting After Urologic Laparoscopic Surgery

The aim of this prospective randomized controlled study was to compare the prophylactic effects of intravenous single dose of ondansetron, ramosetron, and palonosetron on PCA-related nausea and vomiting after urologic laparoscopic surgery.

Inclusion Criteria:

• ASA I or II
• Patients aged (20-65 yr) Undergoing Laparoscopic Nephrectomy
• Patients who want a patient-controlled IV analgesia (IV-PCA)

Exclusion Criteria:

• History of allergy or hypersensitivity to 5-HT3 antagonist
• History of severe postoperative nausea/vomiting
• Prolonged QT interval on preoperative EKG
• Hypokalemia, Hypomagnesemia
• Intestinal obstruction
• Pregnant female or breast feeding mother