Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)

Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome, Sepsis, Chronicle Liver Disease or After Lysis on Intensive Care Units

In this study patients with

1. chronicle liver diseases

   • primary biliary cirrhosis
   • primary sclerosing cholangitis
   • alcoholic liver cirrhosis
   • hepatitis b or C
   • Wilson's disease
   • cryptogenic cirrhosis

2. Septic Inflammatory Response Syndrome (SIRS)

   • sepsis
   • septic shock

3. patients after lysis

should be included

Blood samples will be gathered from the patients to measure fibrinogen with 5 different methods.

The methods are:

• Clauss fibrinogen
• PT-Derived fibrinogen
• immunoturbidimetric method
• heat-precipitated fibrinogen
• Schulz fibrinogen

The result of these tests will be correlated with laboratory values which are gathered in routine and the clinical outcomes.

Inclusion Criteria:

• SIRS
• sepsis
• septic shock
• chronicle liver disease (MELD-Score >10)
• patient after lysis
• patient agrees

Exclusion Criteria:

• no agreement