In this study patients with

1. chronicle liver diseases

   • primary biliary cirrhosis
   • primary sclerosing cholangitis
   • alcoholic liver cirrhosis
   • hepatitis b or C
   • Wilson's disease
   • cryptogenic cirrhosis

2. Septic Inflammatory Response Syndrome (SIRS)

   • sepsis
   • septic shock

3. patients after lysis

should be included

Blood samples will be gathered from the patients to measure fibrinogen with 5 different methods.

The methods are:

• Clauss fibrinogen
• PT-Derived fibrinogen
• immunoturbidimetric method
• heat-precipitated fibrinogen
• Schulz fibrinogen

The result of these tests will be correlated with laboratory values which are gathered in routine and the clinical outcomes.

Inclusion Criteria:

• SIRS
• sepsis
• septic shock
• chronicle liver disease (MELD-Score >10)
• patient after lysis
• patient agrees

Exclusion Criteria:

• no agreement

patients in intensive care units of the university hospital