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The effect of Antibacterial Nanoparticles, Incorporated in root canal sealer material and in provisional restoration is going to be examined. Two different tests are planned: (1) clinical and radiological evaluation of root canal sealer.(2) An evaluation in the laboratory the efficacy of provisional restoration during root canal treatment.We assume, based on our previous laboratory studies that show antibacterial properties, that the incorporation of the nanoparticels will improve the treatment outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Root canal sealer group+ IABN | Experimental | Device: alkylated polyethylenimine nanoparticles antibacterial evaluation |
|
| Provisional restoration material+ IABN | Experimental | Device: alkylated polyethylenimine nanoparticles antibacterial evaluation |
|
| Experimental- Different root canal sealer+ IABN | Experimental | Device: alkylated polyethylenimine nanoparticles antibacterial evaluation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IABN | Device | Patients with single canal teeth diagnosed with infected pulp and periapical lesion, and need root canal treatment, will be asked to participate in the study. The study group will have their canal sealed with endodontic sealer + the nanoparticles. The control group will have their canal sealed with the conventional sealer alone. The patients will be invited to 4 follow ups during which a clinical and radiological examinations will be performed.While preparing the post, a sample of the sealer will be taken to evaluation in the lab. |
| Measure | Description | Time Frame |
|---|---|---|
| In vitro evaluation | clinical and radiological evaluation of the radiolucent periapical lesion, for the root canal sealer. As for the provisional restoration, in vitro assesment of bacterial growth. | One month for provisional restoration. |
| Measure | Description | Time Frame |
|---|---|---|
| Radiological evaluation of the root canal sealer | clinical and radiological evaluation of the radiolucent periapical lesion, for the root canal sealer. As for the provisional restoration, in vitro assesment of bacterial growth. | 1 year for the root canal sealer. |
| Clinical and in vitro evaluation of the root canal sealer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Perez Davidi, DMD | Contact | 00 972 3 9244859 | michaelperezdavidi@gmail.com | |
| Dana Kesler Shvwero, DMD | Contact | 00 972 77 2003172 | danakesler@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Michael Michael Perez Davidi, DMD | Hadassah Medical Organization | Principal Investigator |
| Ervin Weiss, DMD | Hadassah Medical Organization | Study Chair |
| Itzhak Abramovitz, DMD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hadassah Medical Organization | Recruiting | Jerusalem | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16564083 | Background | Beyth N, Yudovin-Farber I, Bahir R, Domb AJ, Weiss EI. Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans. Biomaterials. 2006 Jul;27(21):3995-4002. doi: 10.1016/j.biomaterials.2006.03.003. Epub 2006 Mar 27. | |
| 17216909 | Background |
| Label | URL |
|---|---|
| Michael Perez Davidi | View source |
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|
| IABN | Device | patients with molar teeth diagnosed with healthy pulp or irreversible pulpitis, and need root canal treatment, will be asked to participate in the study. After cleaning the teeth following a standard protocol, a sterile cotton wool will be placed in the pulp chamber. provisional restoration with and without nanoparticles will seal the teeth between apointments. After a month the cotton wool will be taken out and tansferred to the laboratory. The root canal treatment will continue following the standard protocol. |
|
|
| IABN | Device | Patients with single canal teeth diagnosed with infected pulp and periapical lesion, and need root canal treatment, will be asked to participate in the study. The study group will have their canal sealed with endodontic sealer + the nanoparticles. The control group will have their canal sealed with the conventional sealer alone. The patients will be invited to 4 follow ups during which a clinical and radiological examinations will be performed.While preparing the post, a sample of the sealer will be taken to evaluation in the lab. |
|
|
clinical and radiological evaluation of the radiolucent periapical lesion, for the root canal sealer. As for the provisional restoration, in vitro assesment of bacterial growth.While preparing the post, a sample of the sealer will be taken to evaluation in the lab. |
| 1 year for the root canal sealer. |
| Hadassah Medical Organization |
| Study Chair |
| Dana Kesler Shvero, DMD | Hadassah Medical Organization | Study Chair |
| Slutsky H, Weiss EI, Lewinstein I, Slutzky S, Matalon S. Surface antibacterial properties of resin and resin-modified dental cements. Quintessence Int. 2007 Jan;38(1):55-61. |
| 17140542 | Background | Matalon S, Weiss EI, Gozaly N, Slutzky H. Surface antibacterial properties of compomers. Eur Arch Paediatr Dent. 2006 Sep;7(3):136-41. doi: 10.1007/BF03262554. |
| 18821794 | Background | Yudovin-Farber I, Beyth N, Nyska A, Weiss EI, Golenser J, Domb AJ. Surface characterization and biocompatibility of restorative resin containing nanoparticles. Biomacromolecules. 2008 Nov;9(11):3044-50. doi: 10.1021/bm8004897. Epub 2008 Sep 27. |
| 20583306 | Background | Shvero DK, Davidi MP, Weiss EI, Srerer N, Beyth N. Antibacterial effect of polyethyleneimine nanoparticles incorporated in provisional cements against Streptococcus mutans. J Biomed Mater Res B Appl Biomater. 2010 Aug;94(2):367-371. doi: 10.1002/jbm.b.31662. |