Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication

Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial

The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.

This study is conducted to evaluate the bacterial reduction capability of hydrogel loaded with Nano Calcium Hydroxide and paste form of nano and conventional calcium hydroxide as an intracanal medication. The hydrogel will be synthesized in a new rapid in situ form that can turn from liquid into gel when reaching body temperature. The efficacy of bacterial reduction will be compared with Nano Calcium Hydroxide and conventional Calcium Hydroxide in paste form. The evaluation is to be done by quantitative microbiological assessment of samples which are gained from the root canal before and after intracanal medication placement in roots of permanent molars, having PAI score ≥ 2.

Inclusion Criteria:

• healthy males and females.
• age range between 21-49.
• patients with no physical disability or psychological problems.
• patients presenting with single permanent molar with signs and/or symptoms of apical periodontitis, and having Periapican index ≥ 2.

Exclusion Criteria:

• pregnant women.
• patients with immune-compromised disease.
• patients with complicated systemic diseases.
• patients who took antibiotics within a period of 1 month.
• patients with known sensitivity to the medicaments or pharmaceuticals used in this study.
• Non-restorable teeth including root fractures, and/or advanced periodontal involvement.