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The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.
This study is conducted to evaluate the bacterial reduction capability of hydrogel loaded with Nano Calcium Hydroxide and paste form of nano and conventional calcium hydroxide as an intracanal medication. The hydrogel will be synthesized in a new rapid in situ form that can turn from liquid into gel when reaching body temperature. The efficacy of bacterial reduction will be compared with Nano Calcium Hydroxide and conventional Calcium Hydroxide in paste form. The evaluation is to be done by quantitative microbiological assessment of samples which are gained from the root canal before and after intracanal medication placement in roots of permanent molars, having PAI score ≥ 2.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nano calcium hydroxide in hydrogel form | Experimental | nano calcium hydroxide in hydrogel form is placed in the dry root canals after complete cleaning and shaping procedure.The intracanal medication will be distributed to fill the canals up to the orifice level. |
|
| Nano calcium hydroxide in paste form | Active Comparator | nano calcium hydroxide in paste form is placed in the dry root canals after complete cleaning and shaping procedure. The intracanal medication will be distributed to fill the canals up to the orifice level. |
|
| Conventional calcium hydroxide in paste form | Active Comparator | conventional calcium hydroxide in paste form is placed in the dry root canals after complete cleaning and shaping procedure.The intracanal medication will be distributed to fill the canals up to the orifice level. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Calcium hydroxide | Drug | placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week. |
|
| Measure | Description | Time Frame |
|---|---|---|
| bacterial count | variation in bacterial count between 'nano calcium in hydrogel form' group compared with the other groups. The evaluation will be done by quantitative microbiological assessment test. Three microbiological samples will be collected from each patient. Sterile paper points will be used for collecting intracanal content and it will be sealed in Eppendorf tube until the samples reach laboratory center. Tubes will be labelled as following: S1 - S2 - S3 according to the stage of obtaining the sample. S1: will be obtained after access cavity and patency of canals S2: will be obtained by paper point that match the size of master apical file, after complete cleaning and shaping. S3: will be obtained on the seventh day from the intracanal placement appointment. paper points will be used after complete removal of the intracanal medication from the root canals. | on the seventh day from intercanal medication placement appointment |
| Measure | Description | Time Frame |
|---|---|---|
| periapical healing | The participants will be recalled after at least 6 months, and radiographic examination of the treated tooth will be performed. Preoperative and recall radiographs of teeth will be each assigned a PAI score by 2 blinded, independent, and calibrated examiners according to Periapical index score (PAI) :
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nada T mohamed, bachelor | Contact | +21003577451 | pg.nada92140021@bue.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Shehab Eldin M Saber, doctoral | British University In Egypt | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| british university in Egypt - dentistry collage | Recruiting | Cairo | Egypt |
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| ID | Term |
|---|---|
| D003788 | Dental Pulp Diseases |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D002126 | Calcium Hydroxide |
| ID | Term |
|---|---|
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D017610 | Calcium Compounds |
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| nano calcium hydroxide | Drug | placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week. |
|
| participants will be recalled after 6 months from the obturation for radiographic examination |
| incidence and intensity of pain | patients will receive visual analogue scale (VAS) to help them assess pain presence and intensity each day for the following three days after intracanal placement appointment (after 24 hours, 48 hours, and 72 hours) | Pain intensity will be assessed each day for three days following initial treatment |
| incidence of flare up | Flare up will be presented by 'yes' for developing swelling, and 'no' for not developing swelling. it will be recorded on a chart that will be given to the patients after the initial treatment | incidence of flare up will be recorded each day after the intracanal medication placment visit until the next visit (after seven days) |
| D000838 |
| Anions |
| D007477 | Ions |
| D004573 | Electrolytes |