Effect of Vitamin D Replacement During Winter Months in Patients With Hypertension

Effect of Cholecalciferol on 24-hr ABPM and Vasoactive Hormones in Patients With Hypertension.

High blood pressure is related to increased risk of cardiovascular disease and death, and accounts for approximately 8 mill deaths worldwide each year. Blood pressure exhibits a seasonal variation with a tendency to increase during winter months. Vitamin D deficiency is more common during months where UVB radiation from the sun is absent, and vitamin D has been associated with high blood pressure. This study will evaluate the effect of vitamin D replacement during winter months on blood pressure and vasoactive hormones in patients with high blood pressure.

Inclusion Criteria:

• Well-regulated arterial hypertension
• Office blood pressure > 120/70 mmHg

Exclusion Criteria:

• Pregnancy or nursing
• Cancer
• Alcohol abuse
• Continuous glucocorticoid or NSAID treatment
• 24-hour blood pressure > 150/95 mmHg
• Hypercalcemia