The Influence of Vitamin D on Mineral Metabolism, Blood Pressure and Pulse Wave Analysis in Healthy Individuals

The Influence of Vitamin D on Mineral Metabolism, Blood Pressure and Pulse Wave Analysis in Healthy Individuals. A Randomised Double Blinded Placebo Controlled Trial.

A randomized placebo controlled trial evaluating the effect of the recently recommended high doses of cholecalciferol (3000 IU/day) on mineral metabolism, blood pressure and pulse wave analysis in healthy individuals.

Inclusion Criteria:

• > 18 years old
• p 25OH vitaminD<50nmol/l
• signed informed consent

Exclusion Criteria:

• receiving antihypertensive or antidiabetic treatment
• sarcoidoses
• history of kidney stones
• receiving 1-alfa-hydroxylated vitamin D treatment
• plasma creatinin > 120 micromol/l
• ionised calcium > 1,5 mmol/l
• treatment with calcimimetics
• active malignancy
• intestinal malabsorption
• active pancreatitis
• former hospitalisation due to alcoholic related disease
• using euphoriant drugs
• pregnancy or risk of being pregnant or lactating women
• Known allergy to cholecalciferol capsules