Antibiotic Treatment of Multiple Erythema Migrans

Comparison of Ceftriaxone and Doxycycline for Treatment of Multiple Erythema Migrans

The purpose of this study is to compare the efficacy and safety of 15-day ceftriaxone versus 15-day doxycycline treatment in patients with multiple erythema migrans.

Inclusion Criteria:

• multiple erythema migrans in patients > 15 years

Exclusion Criteria:

• a history of Lyme borreliosis in the past
• pregnancy or lactation
• immunocompromised status
• serious adverse event to doxycycline or beta lactam antibiotic
• taking antibiotic with antiborrelial activity within 10 days