Duration of Antibiotic Treatment of Erythema Migrans

Duration of Antibiotic Treatment of Erythema Migrans. A Randomized Clinical Trial.

The purpose of this study is to compare the efficacy of 15-day versus 10-day doxycycline treatment in patients with erythema migrans.

Inclusion Criteria:

• solitary erythema migrans in patients > 15 years

Exclusion Criteria:

• a history of Lyme borreliosis in the past
• pregnancy or lactation
• immunocompromised status
• serious adverse event to doxycycline
• taking antibiotic with antiborrelial activity within 10 days
• multiple erythema migrans or extracutaneous manifestations of Lyme borreliosis