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Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diltiazem treated group | Experimental | Diltiazem 180mg treated group |
|
| Bisoprolol treated group | Active Comparator | Bisoprolol 5mg treated group |
|
| Candesartan treated group | Active Comparator | Candesartan 32mg treated group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diltiazem treated group | Drug | Diltiazem 180mg for 9 months |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Wall to lumen ratio of fundus vessel | Measurement of change in the ratio of wall thickness to lumen of the fundus vessel from baseline to 9 month follow up | baseline, 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| lipid parameter | Measurement of change in total cholesterol, triglyceride, LDL, small dense LDL, and HDL | baseline, 9 months |
| Serum markers of inflammation | CRP |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hae-Young Lee, MD, PhD | Contact | 82-10-4528-6160 | hylee612@snu.ac.kr | |
| Hyo-Soo Kim, MD, PhD | Contact | 82-2-2072-2226 | hyosoo@snu.ac.kr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| Bisoprolol treated group |
| Drug |
Bisoprolol 5mg for 9 months |
|
| Candesartan treated group | Drug | Candesartan 32mg for 9 months |
|
| baseline, 9 months |
| Change of nitrate need | Measure of change of nitrate need | baseline, 1 months, and 3 months |
| ID | Term |
|---|---|
| D060050 | Angina, Stable |
| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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