Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation

Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation

Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).

Inclusion Criteria:

• Stable angina patients whose coronary lesions is confirmed by angiography or receives PCI
• Unstable Angina/NSTEMI patients who completed PCI for main lesions
• Either systolic > 130mmHg or diastolic > 80mmHg, or patients with anti-hypertensive drugs

Exclusion Criteria:

• STEMI patients within one month
• Variant Angina
• Liver function abnormality or renal failure
• History of Hypersensitivity to testing drugs
• Severe heart failure(NYHA class>3) or uncorrectable hematologic disease
• Woman possible to be pregnant
• Uncontrolled diabetes
• Expected life span < one year