A Pilot Study Exploring Efficacy and Safety of Amlodipine in the Stented Angina Patients

A Pilot Study Exploring Efficacy and Safety of Amlodipine in the Stented Angina Patients

1. OBJECTIVES

   Primary objective to evaluate the difference of the peak oxygen uptake change (VO2 max, mL/kg/min) in amlodipine group against no CCB group at 9 months

   Secondary objectives To evaluate the change of sublingual nitrate use per day against no CCB group at 1 and 3 months To evaluate the change of biomarkers against no CCB group at 9 months

2. SUBJECTS AND CENTERS 212, stable angina patients with angiographically confirmed significant residual stenosis 10, 3rd-grade, teaching hospitals in Korea

Inclusion Criteria:

• Stable angina patient with angiographically confirmed significant residual stenosis
• Stenosis more than 50% in 2 major coronary arteries at least or Stenosis more than 75% in 1 major coronary artery

Exclusion Criteria:

• No other pulmonary/psychiatry/musculoskeletal disorder limiting CPET
• Contraindicated to the CPET (e.g. unstable angina, aortic stenosis, uncontrolled hypertension, uncontrolled asthma, hypoxemia at rest, epilepsy, locomotor disorder, severe hypertension and febrile illness)