Primary Sclerosing Cholangitis (PSC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PSC.

This study is being done to investigate whether genes make people more likely to develop PSC. Discovery of these genes will help us to better understand how PSC developes and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Inclusion Criteria:

• Men, Women, and Children between the ages of 5-90 with a history of PSC.
• PSC patients who have had a liver transplant are eligible.
• Family members (1st degree relatives) of enrolled PSC patients are eligible.

Exclusion Criteria:

• Individuals with no history of PSC or those unable to provide consent.

Subjects who are patients at Mayo Clinic and are seen in the department of Gastroenterology and Hepatology are recruited by mail and carry a diagnosis of Primary Sclerosing Cholangitis (PSC). Subjects who are not Mayo Clinic patients are encouraged to contact the study coordinator by phone or email to request enrollment.