Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC.

This study is being done to investigate whether genes make people more likely to develop PBC. Discovery of these proposed genes will help us better understand how PBC developes, and subsequently, to apply new approaches for its prevention, diagnosis and treatment.

Inclusion Criteria:

• Men and women between the ages of 18-90 who have a history of PBC.
• PBC patients who have undergone a liver transplant are eligible.
• Family members (1st degree relatives) of enrolled PBC patients are eligible.

Exclusion Criteria:

• Individuals with no history of PBC or those unable to provide consent.

Subjects who are patients at Mayo Clinic and are seen in the department of Gastroenterology and Hepatology are recruited by mail and carry a diagnosis of PBC. Subjects who are not Mayo Clinic patients are encouraged to contact the study coordinator by phone or email to request enrollment.