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The Attention Deficit/ Hyperactivity Disorder (ADHD) is a developmental disorder which affects 3 to 5 % of school age children. This disorder persists in the adulthood for 60 % of subjects. Children with ADHD are sleepier during the day than normal children. However, there is no information concerning the diurnal sleepiness of adults with ADHD and the impact of this sleepiness on their driving capacity. The investigators postulate that the negative impact of ADHD is due to an awakening disorder which adds to the attentional disorder. The aim of this study is to estimate both the sleepiness by a Maintenance Wakefulness Test (MWT) and the capacity to drive in adults with ADHD.
The main objective of this study is to estimate both the sleepiness by a Maintenance Wakefulness Test (MWT) and the capacity to drive in adults presenting an ADHD. Duration of participation for each patients will be 7 days. Four days after inclusion, patients will have to stop all psychostimulant treatment. Participants will then spend 24 hours (on days 6 and 7) at the "Groupe d'Etudes Neurophysiologie Pharmacologie Sommeil et Sommnolence"(GENPPHASS) in the "Centre Hospitalier Universitaire"(CHU) of Bordeaux. During this time, they will undergo complete polysomnography.The next day, they will perform a Maintenance Wakefulness Test (MWT). A neuropsychological evaluation of one hour will also be done. Finally, a driving test on a simulator will be performed.
Study significance: patients will benefit from an objective exploration of their sleep (with possibly, a sleep disorder discovery) and from a specific treatment. This study will demonstrate the necessity to investigate daytime function (sleepiness and performance) and the sleep quality of patients with ADHD. It will also demonstrate that part of the adults with ADHD handicap is based on an awakening disorder which adds to the attentional disorder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TDA/H | Experimental |
| |
| Sleep apnea patient | Other |
| |
| Healthy volunteer | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polysomnography | Other | Sleep study monitoring |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of the average sleep latency during the Maintenance Wakefulness Test | Day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| The number of line crossing on the driving simulator test | Day 7 | |
| Standard deviation of the average position of the vehicle in the driving simulator test | Day 7 | |
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Inclusion Criteria:
Group for ADHD:
For the apneic group:
For the control group:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anouck AMESTOY, Dr | University Hospital Bordeaux (France) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux | Bordeaux | 33076 | France | |||
| Hôpital Charles Perrens |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25610980 | Derived | Bioulac S, Chaufton C, Taillard J, Claret A, Sagaspe P, Fabrigoule C, Bouvard MP, Philip P. Excessive daytime sleepiness in adult patients with ADHD as measured by the Maintenance of Wakefulness Test, an electrophysiologic measure. J Clin Psychiatry. 2015 Jul;76(7):943-8. doi: 10.4088/JCP.14m09087. |
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| Maintenance Wakefulness Test |
| Other |
Sleep latency testing at 10 am, 12 am, 2 pm and 4 pm. |
|
| Neuropsychological evaluation | Behavioral | Neuropsychological evaluation for cognitive functions study |
|
| Driving test on a simulator | Other | Driving simulator test during wich a camera register different parameters as the position of the vehicle. |
|
| Score on Epworth Sleepiness scale |
| Day 7 |
| Reaction time and the percentage of error in the cognitive tests | Day 7 |
| Bordeaux |
| 33076 |
| France |
| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| D013035 | Spasm |
| D000077260 | Sleepiness |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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