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The primary purpose of this study is to determine the effects of methylphenidate versus placebo on driving ability of adult ADHD patients.
This study was set-up to examine the controversial issue whether or not it is safe to drive a car or not when treated with methylphenidate.
On-the-road driving tests during normal traffic are conducted to determine the effects of methylphenidate versus placebo on driving ability of adult ADHD patients.In addition, two laboratory tests are conducted to examine memory functioning and inhibitory control.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| methylphenidate | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Driving test:Standard Deviation of Lateral Position (SDLP, cm);i.e. the weaving of the car [single dose effects] |
| Measure | Description | Time Frame |
|---|---|---|
| Other Driving test parameters: Standard Deviation of Speed, mean speed, mean lateral position. | ||
| Memory test: immediate & delayed word recall, delayed recognition.[single dose effects] | ||
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joris Verster, PhD | Utrecht Institute for Pharmaceutical Sciences | Principal Investigator |
| Edmund Volkerts, PhD | Utrecht Institute for Pharmaceutical Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Utrecht Institute for Pharmaceutical Sciences | Utrecht | 3508 TB | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20645078 | Derived | Verster JC, Bekker EM, Kooij JJ, Buitelaar JK, Verbaten MN, Volkerts ER, Olivier B. Methylphenidate significantly improves declarative memory functioning of adults with ADHD. Psychopharmacology (Berl). 2010 Oct;212(2):277-81. doi: 10.1007/s00213-010-1952-2. Epub 2010 Jul 20. |
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| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D008774 | Methylphenidate |
| ID | Term |
|---|---|
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Continuous Performance test: RT, %errors [single dose effects] |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |