Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
OBJECTIVE: To evaluate the efficacy of prevention of contrast induced nephropathy in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
DESIGN: Prospective study. SETTING: Three-center study Acute kidney injury was defined as a rise in creatinine >25% from baseline Serum creatinine will be measured at baseline and each day for the following 3 days and at 30 days.
Patients will be randomised to:
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard treatment | Active Comparator | Hydration |
|
| Combined Acetylcystein and Sodium Bicarbonat | Active Comparator |
| |
| Sodium Bicarbonate | Active Comparator |
| |
| Acetylcystein for 2 days | Active Comparator | Standard treatment + acetylcystein for 2 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydration | Other | Saline hydration |
| |
| Acetylcysteine |
| Measure | Description | Time Frame |
|---|---|---|
| Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI | Rise in creatinine >25% from baseline to day 3 | from baseline to day 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI | Rise in creatinine >25% from baseline to day 30 | from baseline to day 30 |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Per Thayssen, MD DMSci | Odense University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Odense University Hospital | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24714489 | Derived | Thayssen P, Lassen JF, Jensen SE, Hansen KN, Hansen HS, Christiansen EH, Junker A, Ravkilde J, Thuesen L, Veien KT, Jensen LO. Prevention of contrast-induced nephropathy with N-acetylcysteine or sodium bicarbonate in patients with ST-segment-myocardial infarction: a prospective, randomized, open-labeled trial. Circ Cardiovasc Interv. 2014 Apr;7(2):216-24. doi: 10.1161/CIRCINTERVENTIONS.113.000653. Epub 2014 Apr 8. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000111 | Acetylcysteine |
| D017693 | Sodium Bicarbonate |
| ID | Term |
|---|---|
| D003545 | Cysteine |
| D000603 | Amino Acids, Sulfur |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Drug |
Acetylcystein tablets for 2 days |
|
| Sodium bicarbonate | Drug | Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours |
|
| Combined Acetylcystein and Sodium Bicarbonate | Drug | Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours combined with acetylcystein tablets for 2 days |
|
| D000596 |
| Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001639 | Bicarbonates |
| D002254 | Carbonates |
| D002255 | Carbonic Acid |
| D017554 | Carbon Compounds, Inorganic |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |