The Acetylcysteine for Contrast-Induced Nephropathy Trial

A Pragmatic Randomized Clinical Trial Evaluating the Effect of Acetylcysteine for Contrast-induced Nephropathy

The purpose of this study is to evaluate the efficacy of acetylcysteine compared to placebo for the contrast-induced nephropathy prevention, between 48 and 96 hours after procedures that use contrast.

Contrast-induced nephropathy is defined as an increase of 25% in serum creatinine before the procedure.

Inclusion Criteria:

At least one of the following criteria:

• Aged more than 70 years-old
• Chronic renal failure (defined as serum creatinine higher than 1.5mg/dL within the last 3 months)
• Diabetes mellitus
• Congestive heart failure or ventricular disfunction (left ventricular ejection fraction less than 0.45)
• Shock or intra-aortic balloon pump use
• Urgency or emergency procedures

Exclusion Criteria:

• Pregnant women, breastfeeding or aged below 45 years-old and with no efficacious contraceptive methods.
• Patients in dialysis
• Previous inclusion in this trial
• Patient refusal to informed consent
• Pacientes com Infarto Agudo do Miocárdio com supradesnivelamento do segmento S-T nos quais não seja possível administrar o protocolo de hidratação pré e pós-procedimento.