Paracetamol Metabolism in Post Operative Conditions

Paracetamol Metabolism in Post Operative Conditions

Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)

D-15 to D0: selection

• patient information and non-opposition obtained
• inclusion and non inclusion criteria check
• clinical exam

D-1 to D0 : 24 hours diuresis

D0 : operation day

Before anesthesia :

• urine collection (paracetamol metabolites dosage)
• blood sampling (glutathion and liver function test)

Surgery:

• 1st paracetamol intake before closing
• Then administration every 6 hours

D1 to D4 :

• 24 hours urine collection (metabolites dosage)
• blood sampling et D1 and D4(glutathion and liver function test)

D5 : final clinical exam

Inclusion Criteria:

• aortic surgery
• treatment with intraveinous paracetamol (4 grammes daily during 4 days)
• patient agrees to participate

Exclusion Criteria:

• - patient disagrees
• paracetamol contra-indication
• paracetamol intake 5 days before surgery