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Evaluate the modified GDT as a measure of key metabolic characteristics in healthy subjects and those with type 2 diabetes mellitus
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Other | Beta cell function by frequently sampled intravenous glucose tolerance test |
|
| Arm 2 | Other | Modified glucose disposal test assessment of insulin sensitivity, endogenous glucose production and insulin secretion |
|
| Arm 3 | Other | Endogenous glucose production and insulin sensitivity by isotope dilution and isoglycemic, heperinsulinemic clamp |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insulin, glucose and staple isotopes | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose (labeled and unlabeled), insulin and c-peptide will be measured to calculate insulin sensitivity, endogenous glucose production and insulin secretion | within 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Characterize the patterns of intermediate metabolites in healthy subjects and subjects with type 2 diabetes mellitus | within 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bristol-Myers Squibb | Bristol-Myers Squibb | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Profil Institute For Clinical Research, Inc. (Picr) | Chula Vista | California | 91911 | United States |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D007328 | Insulin |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D011384 | Proinsulin |
| D061385 | Insulins |
| D010187 | Pancreatic Hormones |
| D036361 | Peptide Hormones |
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| D006728 |
| Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |