A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)

A Randomized Clinical Trial to Evaluate Glucose-Dependent Insulinotropic Effects of a Single Dose of a DPP-4 Inhibitor in Lean Healthy Males

This study will evaluate the effect of a single dose of sitagliptin on glucose dependent insulin secretion using a meal tolerance test (MTT) during a hyperglycemic clamp (HCG) procedure.

Inclusion Criteria:

• Subject is an Asian Indian male between 18 to 45 years of age
• Subject is in good health
• Subject is a nonsmoker or has not used nicotine-containing products for six months
• Subject is willing to avoid strenuous activity

Exclusion Criteria:

• Subject has a history of stroke, seizures, or major neurological disorders
• Subject has irritable bowel disease or recurrent nausea, vomiting, diarrhea, or abdominal pain
• Subject has a history of high blood pressure requiring treatment
• Subject has history of cancer
• Subject has a history of diabetes