Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

Inclusion Criteria:

• Healthy volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
• Diabetes
• Hypertension
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin