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The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy male participants |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cross sectional study | Other | This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating serum A-FABP levels | 12 weeks | |
| Circulating serum leptin levels | 12weeks | |
| Circulating serum adiponectin levels |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy male participats who underwent a medical health check in the health promotion center in Korea Guro University
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| Name | Affiliation | Role |
|---|---|---|
| Kyung Mook Choi, MD.PhD | Korea University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hye Jin Yoo | Seoul | 152-703 | South Korea |
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whole blood, plasma, serum
| 12 weeks |
| Carotid intima-media thickness levels measured using ultrasonography | 12 weeks |
| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D003430 | Cross-Sectional Studies |
| ID | Term |
|---|---|
| D016021 | Epidemiologic Studies |
| D016020 | Epidemiologic Study Characteristics |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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