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| ID | Type | Description | Link |
|---|---|---|---|
| KC/KE-10-0021/FR-3 | Other Identifier | Research Ethics committee (Kowloon Central/Kowloon East) |
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Randomized double blind placebo controlled trial on transversus abdominus plane block approached from abdominal cavity, in patients undergoing total abdominal hysterectomy.
Potential advantages compared to percutaneous approach are decrease in risk of visceral injury as it is under direct visual and tactile guidance, ease of approach in obese patients, short theatre time for administration, easy to administer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.5% Ropivacaine | Active Comparator | group receiving TAP block (0.5% ropivacaine at TAP plane) |
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| normal saline | Placebo Comparator | group receiving placebo (saline) at TAP plane |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transversus abdominis plane block | Procedure | This intraabdominal approach to TAP block is being used regularly by gynaecological surgeons in this hospital now. To be performed bilaterally before surgical wound closure by an experienced surgeon who initially undergo initial observation by investigator to ensure uniformity in technique. Local anaesthetic or placebo solution will be injected to TAP with blunt needle from within abdominal cavity under visual and tactile guidance at the triangle of Petit, after feeling one 'pop' through the transversus abdominis muscle to the TAP layer. After careful aspiration to exclude vascular puncture, 1.5mg/kg of 0.5% ropivacaine or 0.3ml/kg of 0.9% saline placebo will be injected to each side slowly while observing for signs of toxicity. |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative 24hr morphine consumption | The primary objective of this study is to demonstrate the effectiveness of tranversus abdominis plane block using the intraabdominal approach in reducing postoperative 24 hours morphine consumption after total abdominal hysterectomy (TAH) where time 0 is taken as time of arrival at PACU. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| morphine consumption on arrival to post-anaesthetic care unit(PACU) and 4, 12 and 24 hours after. | • Assess and compare the morphine consumption on arrival to post-anaesthetic care unit(PACU) and 4, 12 and 24 hours after. | 24hrs |
| Degree on pain according to numerical pain score on arrival to post-anaesthetic care unit(PACU) and 4, 12 and 24 hours after during rest and movement (cough |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wing Yee Lillian Choy, MBBS (HK) | Contact | 3513 4245 | cwy027@ha.org.hk |
| Name | Affiliation | Role |
|---|---|---|
| Wing Yee Lillian Choy, MBBS (HK) | United Christian Hospital, Hospital Authority | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department Of Anaesthesiology, Pain medicine and Operating Services. United Christian Hospital | Recruiting | Kwun Tong | Kowloon | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17179269 | Background | McDonnell JG, O'Donnell B, Curley G, Heffernan A, Power C, Laffey JG. The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial. Anesth Analg. 2007 Jan;104(1):193-7. doi: 10.1213/01.ane.0000250223.49963.0f. | |
| 19020158 | Background | Carney J, McDonnell JG, Ochana A, Bhinder R, Laffey JG. The transversus abdominis plane block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesth Analg. 2008 Dec;107(6):2056-60. doi: 10.1213/ane.0b013e3181871313. |
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| 24hrs |
| incidence of nausea and vomiting | 24hours postoperatively |
| 19749115 | Background | Bonnet F, Berger J, Aveline C. Transversus abdominis plane block: what is its role in postoperative analgesia? Br J Anaesth. 2009 Oct;103(4):468-70. doi: 10.1093/bja/aep243. No abstract available. |