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Blood lactate levels in patients receiving typical or atypical antipsychotics have not been described in the literature.
The goal of this study is to assess the dynamics of lactate levels in the blood from typical or atypical antipsychotics not confounded by prior antipsychotic treatments, the investigators conducted a prospective study of lactate levels in patients receiving antipsychotic medication. The investigators hypothesized that 6 months of treatment with haloperidol or olanzapine would result in a change in blood lactate levels and extrapyramidal side effects.
The aim of this study was to compare the blood lactate levels in patients receiving typical or atypical antipsychotics.
Subjects included sixty patients with psychotic disorder were assigned to treatment for 6 months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale (ESRS) were assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Antipsychotic treatment | Patients were not taking any medications - apart from the prescribed antipsychotic - for a period of 1 month prior to the study with psychotic relapse or newly diagnosed psychotic disorder were recruited from psychiatric inpatient and outpatient clinics of the Split Clinical Hospital. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Haloperidol or olanzapine | Drug | Haloperidol tablet - 5 mg twice daily (morning and evening) by mouth Olanzapine tablet - 5 mg twice daily (morning and evening) by mouth |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood lactate levels | 1 month | |
| Blood lactate levels | 3 months | |
| Blood lactate levels | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Extrapyramidal side effects | The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study. | 1 month |
| Extrapyramidal side effects |
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Inclusion Criteria:
Exclusion Criteria:
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The population consists of patients from the psychiatric inpatient and outpatient sections of a primary care hospital.
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| Name | Affiliation | Role |
|---|---|---|
| Trpimir Glavina, MD | University of Split | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Split Clinical Hospital Center | Split | 21000 | Croatia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21328719 | Derived | Glavina T, Mrass D, Dodig T, Glavina G, Pranic S, Uglesic B. Blood lactate levels in patients receiving first- or second- generation antipsychotics. Croat Med J. 2011 Feb;52(1):41-7. doi: 10.3325/cmj.2011.52.41. |
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| ID | Term |
|---|---|
| D009069 | Movement Disorders |
| D000140 | Acidosis, Lactic |
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
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| ID | Term |
|---|---|
| D006220 | Haloperidol |
| D000077152 | Olanzapine |
| ID | Term |
|---|---|
| D002090 | Butyrophenones |
| D007659 | Ketones |
| D009930 | Organic Chemicals |
| D001569 | Benzodiazepines |
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|
The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study. |
| 3 months |
| Extrapyramidal side effects | The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study. | 6 months |
| D008659 |
| Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001552 |
| Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |