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| ID | Type | Description | Link |
|---|---|---|---|
| LONG 10-01 | Other Identifier | University Hospital Ghent |
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Poor recruitment rate.
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| Name | Class |
|---|---|
| Nationaal Kankerplan | UNKNOWN |
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Surgical resection with mediastinal lymph node sampling is currently the therapy of choice for early stage (I-II) non-small cell lung cancer (NSCLC). Selected patients unwilling or unable to tolerate surgery are referred for so-called 'curative' high dose radiotherapy. This has shown to result in a long term local disease control rate and a high cancer specific survival.
The current trial addresses the relationship between blood and tissue biomarkers, bio-imaging and pathology in patients with early stage NSCLC treated with hypofractionated radiation therapy and surgery.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hypofractionated radiation therapy followed by surgery | Radiation | hypofractionated radiation therapy followed by surgery |
| Measure | Description | Time Frame |
|---|---|---|
| pathological effects of hypofractionated radiation therapy | To describe the pathological effects of hypofractionated radioation therapy (RT) and to address the relationship with blood and tissue biomarkers and bio-imaging. | at 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| clinical response rate | from 2 to 5 years | |
| the accuracy of clinical mediastinal staging | from 2 to 5 years | |
| the complication rate |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Van Meerbeeck, MD, PhD | University Hospital Ghent, Belgium | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Antwerp | Antwerp | Belgium | ||||
| University Hospital Ghent |
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| Label | URL |
|---|---|
| website of University Hospital Ghent | View source |
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| from 2 to 5 years |
| local, regional or distant failure | from 2 to 5 years |
| progression free survival | from 2 to 5 years |
| disease specific overall survival | from 2 to 5 years |
| overall survival | from 2 to 5 years |
| Ghent |
| Belgium |