Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subjects

This study aims to determine, in obese subjects, the antisecretory effect of a single dose of placebo, rabeprazole 20 mg and omeprazole 20 mg using 24h gastric pH monitoring, in a prospective, monocentre, randomized manner. Monitorings are separated between 6 and10 days. The main outcome criteria of analysis is the percentage of time with gastric pH above 3 during 24hours.

Inclusion Criteria:

• Helicobacter negative obese subject (BMI 30 to 40),
• 18 to 55 years old,
• normal hepatic biology and morphology (echography)
• Contraceptive methods in women.

Exclusion Criteria:

• Subjects with previous abdominal surgery, with diabetic or immunosuppressive treatment.