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| Name | Class |
|---|---|
| National Science and Technology Council, Taiwan | OTHER_GOV |
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Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise training | Experimental | Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer. |
|
| Control group | Active Comparator | Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise training | Behavioral | Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer. |
| Measure | Description | Time Frame |
|---|---|---|
| Exercise capacity | Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS | 8 weeks after the start of the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Imaging of muscle | Measured by MRS | 8 weeks and 16 weeks after the start of the intervention |
| Analysis of venous blood sample | Analysis of circulating VEGF-A and myostatin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ying-Tai Wu, Ph.D | National Taiwan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Taipei | 100 | Taiwan |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D010353 | Patient Education as Topic |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Usual care | Other | Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital. |
|
|
| 8 weeks andd 16 weeks after the start of the intervention |
| Quality of life | Measured by questionnaire | baseline, 8 weeks, 16 weeks |
| Exercise capacity | Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS | 16 weeks after the start of the intervention |
| Muscle function | Isokinetic muscle strength and endurance with Biodex | 8 weeks and 16 weeks after the start of the intervention |
| Physical activity | Measured with 7-day recall questionnaire | 8 weeks andd 16 weeks after the start of the intervention |
| Dietary intake | Measured with 24-hour recall questionnaire | 8 weeks andd 16 weeks after the start of the intervention |
| Body composition | Body mass index calculated with body weight and height % body fat abd free-fat mass with BIA | 8 weeks andd 16 weeks after the start of the intervention |
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006266 | Health Education |
| D011314 | Preventive Health Services |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |