Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients

Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on

1. circulating VEGF-A
2. muscle growth and function
3. Myostatin

Inclusion Criteria:

• Age 40-75 years
• Advanced NSCLC
• Eastern Cooperative Oncology Group performance status of 0 or 1
• Targeted therapy for at least 8 weeks
• Stable condition

Exclusion Criteria:

• Severe metastasis, cardiopulmonary or musculoskeletal conditions may affect participation in exercise
• Do not understand the verbal or written instructions