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| Name | Class |
|---|---|
| University of South Carolina | OTHER |
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Cancer and its treatment can have profound effects on skeletal muscle, the most well-recognized being atrophy, weakness and diminished oxidative capacity. These adaptations negatively impact quality of life, treatment decisions and survival. Despite these consequences, the factors promoting these adaptations remain poorly defined and understudied in human patients. To address this gap in knowledge, our goal in this study is to examine the role of muscle disuse as a regulator of muscle size and function in human cancer patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise | Experimental | Lung cancer patients will undergo unilateral resistance exercise 3 times per week for 8 weeks during cancer treatment, while the other leg remains unexercised and will serve as a within-subject control. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Unilateral lower limb resistance exercise will be performed 3 times per week for 8 weeks in non-small cell lung cancer patients on only one leg, while the contralateral leg serves as a non-exercising control. |
| Measure | Description | Time Frame |
|---|---|---|
| Cross-sectional area of skeletal muscle fibers | Cross-sectional area of skeletal muscle fibers will be evaluated using immunohistochemistry, with specification of all relevant muscle fiber types | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| Single muscle fiber contractile function | Segments of chemically-skinned single human muscle fibers will be assessed for cellular and molecular contractile parameters under maximal calcium-activated conditions, with muscle fiber type determined post-measurement by gel electrophoresis | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| Mitochondrial content | Mitochondrial content will be assessed by electron microscopy. | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| Mitochondrial function | Mitochondrial function will be assessed on isolated mitochondria | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Whole muscle size | Whole muscle size will be measured by computed tomography at the mid-thigh level. | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| Whole muscle isometric function |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael J. Toth, Ph.D. | University of Vermont | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vermont College of Medicine | Burlington | Vermont | 05405 | United States |
Research data (deidentified) which documents, supports and validates research findings will be stored on the University of Vermont College of Medicine computer system and will be made available upon final acceptance for publication of the major findings from the proposed studies. This includes raw data generated from all clinical and laboratory-based assessments under a data-sharing agreement.
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Whole muscle volitional contractile function will be measured by isometric Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks by isometric dynamometry.
| Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| Whole muscle isokinetic function | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks by isokinetic dynamometry | Difference between the change in the exercised and non-exercised leg from baseline to 8 weeks |
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |