The Effect of Green Tea or Cocoa Extracts in Endothelial Dysfunction in Patients With Diabetes Mellitus

Randomized Clinical Trial, Placebo Controlled, With Parallel Groups to Investigate Whether Green Tea or Cocoa Extracts Improves Endothelial Dysfunction in Patients With Diabetes Mellitus and Nephropathy and Hypertension

The purpose of this study is to determine whether green tea or cocoa extracts are effective in improve endothelial dysfunction in patients with diabetes mellitus and nephropathy and arterial hypertension.

Inclusion Criteria:

• Type 1 or type 2 diabetes mellitus
• Diabetic nephropathy
• Hypertension

Exclusion Criteria:

• GFR < 30 ml/min/1.73m2
• Serum K > 5.5 mEq/L
• Age < 18 y
• Pregnancy
• Breast feeding
• Cocoa or green tea intolerance
• Alcohol and drugs abuse
• Incapacity to understand the information related to the study