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| Name | Class |
|---|---|
| The Hospital for Sick Children | OTHER |
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The purpose of this study is to determine the effect of remote ischemic preconditioning on exercise capacity in patients with heart failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| remote ischemic preconditioning | Experimental | 4 cycles of 5 mins upper limb ischemia induced by blood pressure cuff inflation 20mmHg above systolic blood pressure |
|
| Sham control | Sham Comparator | 4 x 5 mins of upper limb blood pressure cuff inflation to 10mmHg (non-occlusive) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischemic preconditioning | Other | 4 cycles x 5 mins upper limb blood pressure cuff inflation 20mmHg above systolic blood pressure |
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| Measure | Description | Time Frame |
|---|---|---|
| Exercise performance - VO2, exercise time, exercise workload, anaerobic threshold | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toronto General Hospital | Toronto | Ontario | M5G 2N2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40315243 | Derived | Brindle HE, Tetsa-Tata D, Edwards T, Choi EM, Kasonia K, Aboubacar S, Mambula G, Kavunga-Membo H, Grais R, Johnson J, Bausch DG, Muyembe-Tamfum JJ, Ama IS, Lees S, Watson-Jones D, Camacho A, Roberts CH. Using an analogue-digital hybrid clinical data management platform during a two-dose preventive Ebola virus vaccine trial in Goma, the Democratic Republic of the Congo. PLOS Glob Public Health. 2025 May 2;5(5):e0004487. doi: 10.1371/journal.pgph.0004487. eCollection 2025. | |
| 25181050 |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D018487 | Ventricular Dysfunction, Left |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D018754 | Ventricular Dysfunction |
| D001519 | Behavior |
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| Sham Control | Other | 4 cycles x 5mins blood pressure cuff inflation to 10mmHg |
|
| Derived |
| McDonald MA, Braga JR, Li J, Manlhiot C, Ross HJ, Redington AN. A randomized pilot trial of remote ischemic preconditioning in heart failure with reduced ejection fraction. PLoS One. 2014 Sep 2;9(9):e105361. doi: 10.1371/journal.pone.0105361. eCollection 2014. |