Perioperative Melatonin in Lumbar Laminectomy

Perioperative Analgesic and Anxiolytic Effect of Melatonin in Patients Undergoing Lumbar Laminectomy

Patients undergoing lumbar laminectomy surgery will receive either 5 or 10 mg melatonin or placebo once the evening before surgery and again 90 minutes before surgery. Pain and anxiety will be assessed over the 24 hour period following surgery.

Inclusion Criteria:

• age 18 to 65 years old
• ASA status 1-3
• having lumbar laminectomy 2 to 3 levels with or without fusion

Exclusion Criteria:

• receiving emergent procedure
• surgery for neoplastic spine lesion
• allergy to melatonin or its non-medicinal ingredients
• allergy or contraindication
• BMI over 35 or or less than 20 kg/m2
• pregnancy or breastfeeding
• failure to provide informed consent