Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery.

Inclusion Criteria:

• Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under IV sedation
• Ages 18-35
• American Society of Anesthesiologists (ASA) Class I or II
• English or Spanish speaking patients
• Capacity to sign informed consent

Exclusion Criteria:

• Allergies to melatonin, opioids, or other Over-the-counter (OTC) pain medications
• Anyone currently taking melatonin for any reason
• Cases under local anesthesia
• ASA class III or higher
• Sleep disorder (insomnia/narcolepsy)
• Current or past history of substance abuse
• Chronic pain
• Language/communication barrier
• Psychiatric disease/ Mental impairment
• Current or past use of psychotropic drugs
• Pregnancy
• Renal or hepatic impairment
• BMI >35