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| ID | Type | Description | Link |
|---|---|---|---|
| 1I01RX000304-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Texas A&M University | OTHER |
| Boston University | OTHER |
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Functional recovery is of the utmost importance to evaluate in our returning Operation Enduring and Iraqi Freedom Veterans so that we can better understand their needs and experiences during the readjustment process from warzone to civilian life. Although most soldiers are resilient, concerning rates of PTSD (12-20%) and depression (14-15%) have been found, and as many as 24-35% report drinking more alcohol than they intended (Hoge et al., 2004). The current study proposes to follow returning Veterans for a one-year period to evaluate factors that influence the readjustment process and functional impairment. This information should guide the development of early intervention and treatment programs to help recovery.
The proposed longitudinal study aims to better understand the functioning of returning Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) OEF/OIF Veterans over time and to identify potentially malleable resilience factors associated with higher levels of functioning. A total of 300 returning OEF/OIF Veterans will be followed for a one-year period. Veterans will complete a baseline assessment, followed by three follow-up assessments (two self-report assessments mailed at 4- and 8-months post-baseline and a one-year in-person follow-up assessment that repeats many of the baseline clinician-administered assessments). Multiple functional outcomes will be evaluated, including occupational, family, social, and physical functioning. The specific aims include: 1) identifying whether a "dose-response" relationship exists between level of exposure to stressors (pre-deployment, deployment-related, and post-deployment) and functioning over time; 2) examining whether potentially malleable resilience factors predict higher levels of functioning in returning Veterans over time; 3) examining whether psychopathology predicts lower levels of functioning in returning Veterans over time; 4) testing the theoretical model that psychopathology partially mediates the effects of stress, social support, coping, and neurocognition on functioning over time; 5) examining whether changes in the use of healthy coping strategies, social support, post-deployment stress, and psychopathology predict changes in functioning over time; and 6) exploring whether stress, social support, coping, neurocognition, and psychopathology have differential effects on specific aspects of functioning (e.g., occupational, family, social, and physical functioning) over time. The long-term aim of this research is to develop evidence-based early intervention and treatment programs designed to assist returning OEF/OIF Veterans with achieving optimal functioning when reintegrating into civilian life. In keeping with the VHA's goal of operationalizing principles of recovery and rehabilitation in treatment planning, this research should provide a platform of empirical data to assist with the further development of meaningful early intervention and treatment programs to assist OEF/OIF Veterans with the post-war readjustment process over time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Operation Enduring Freedom and Operation Iraqi Freedom Veterans |
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| Measure | Description | Time Frame |
|---|---|---|
| World Health Organization Disability Assessment Schedule II (WHODAS II) | Participants complete the WHODAS II at baseline, 4 months, 8 months, and 12 months. The WHODAS II measures general disability related to multiple domains (i.e., understanding and communicating, getting around, self care, getting along with people, life activities, work/school, participation in society). Total scores range from 1 (no disability) to 5 (extreme/cannot do), with higher scores indicating more impairment. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Inventory of Psychosocial Functioning (IPF) | 80-item self-report measure of psychosocial functioning across multiple domains (e.g., family, social, day-to-day activities). Items are rated on a 7-point scale ranging from 0 ("never") to 6 ("always"). Lower scores indicate more positive outcomes. | one year |
| Quality of Life Scale (QLS) |
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Inclusion Criteria:
To be eligible, participants must be:
Exclusion Criteria:
Veterans will be excluded if they:
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Operation Enduring Freedom and Operation Iraqi Freedom Veterans
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| Name | Affiliation | Role |
|---|---|---|
| Sandra B Morissette, PhD | Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX | Waco | Texas | 76711 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22350690 | Background | Dolan S, Martindale S, Robinson J, Kimbrel NA, Meyer EC, Kruse MI, Morissette SB, Young KA, Gulliver SB. Neuropsychological sequelae of PTSD and TBI following war deployment among OEF/OIF veterans. Neuropsychol Rev. 2012 Mar;22(1):21-34. doi: 10.1007/s11065-012-9190-5. Epub 2012 Feb 18. | |
| 25082488 | Background | Konecky B, Meyer EC, Marx BP, Kimbrel NA, Morissette SB. Using the WHODAS 2.0 to assess functional disability associated with DSM-5 mental disorders. Am J Psychiatry. 2014 Aug;171(8):818-20. doi: 10.1176/appi.ajp.2014.14050587. No abstract available. |
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A total of 345 participants were consented into the study, after which final eligibility was determined during the baseline assessment (see inclusion/exclusion criteria). Of the 345 enrolled, 309 met inclusion criteria and were deemed eligible for follow-up in the longitudinal study.
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| ID | Title | Description |
|---|---|---|
| FG000 | OEF/OIF/OND Veterans | Operations Enduring Freedom, Iraqi Freedom and New Dawn Veterans |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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A total of 345 participants were enrolled (signed informed consent), of which 309 met final eligibility criteria. Results are analyzed using the 309 eligible enrolled participants.
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| ID | Title | Description |
|---|---|---|
| BG000 | OEF/OIF/OND Veterans | Operations Enduring Freedom, Iraqi Freedom and New Dawn Veterans |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | World Health Organization Disability Assessment Schedule II (WHODAS II) | Participants complete the WHODAS II at baseline, 4 months, 8 months, and 12 months. The WHODAS II measures general disability related to multiple domains (i.e., understanding and communicating, getting around, self care, getting along with people, life activities, work/school, participation in society). Total scores range from 1 (no disability) to 5 (extreme/cannot do), with higher scores indicating more impairment. | A total of 345 participants were enrolled, of which 309 were deemed eligible. Analyses are conducted with the total sample N = 309, followed over time. Sample sizes vary over time due to attrition and missing data. | Posted | Mean | Standard Deviation | units on a scale | one year |
|
Adverse event data were collected for a one year period (baseline to final assessment at 12 months).
A total of 345 were enrolled, of which 309 were determined to be eligible. No adverse events occurred at the baseline assessment. Adverse events were reported with respect to the 309 eligible participants followed over time.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | OEF/OIF/OND Veterans | Operations Enduring Freedom, Iraqi Freedom and New Dawn Veterans |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| hospitalized for suicidal ideation/attempt | Psychiatric disorders | Systematic Assessment |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Visit to ER for chest pain | Gastrointestinal disorders | Systematic Assessment |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Sandra B. Morissette, Ph.D. | VISN 17 Center of Excellence for Research on Returning War Veterans | 254-297-5170 | sandra.morissette@va.gov |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| D003866 | Depressive Disorder |
| D000437 | Alcoholism |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
| D019964 | Mood Disorders |
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Quality of life measure of functioning scored on a 1 (delighted) to 7 (terrible) scale. Scores are summed with higher scores indicating lower quality of life. Total scores range from 16 - 112. |
| one year |
| Clinician Administered PTSD Scale (CAPS-5) | Total scores reflecting PTSD symptom severity. Scores ranging from 0-136 (higher score = more severe). | one year |
| 21785719 | Result | Greenawalt DS, Tsan JY, Kimbrel NA, Meyer EC, Kruse MI, Tharp DF, Gulliver SB, Morissette SB. Mental Health Treatment Involvement and Religious Coping among African American, Hispanic, and White Veterans of the Wars of Iraq and Afghanistan. Depress Res Treat. 2011;2011:192186. doi: 10.1155/2011/192186. Epub 2011 Jul 18. |
| 22121940 | Result | Morissette SB, Woodward M, Kimbrel NA, Meyer EC, Kruse MI, Dolan S, Gulliver SB. Deployment-related TBI, persistent postconcussive symptoms, PTSD, and depression in OEF/OIF veterans. Rehabil Psychol. 2011 Nov;56(4):340-50. doi: 10.1037/a0025462. |
| 24612971 | Result | Debeer BB, Kimbrel NA, Meyer EC, Gulliver SB, Morissette SB. Combined PTSD and depressive symptoms interact with post-deployment social support to predict suicidal ideation in Operation Enduring Freedom and Operation Iraqi Freedom veterans. Psychiatry Res. 2014 May 30;216(3):357-62. doi: 10.1016/j.psychres.2014.02.010. Epub 2014 Feb 17. |
| 24942672 | Result | Stock EM, Kimbrel NA, Meyer EC, Copeland LA, Monte R, Zeber JE, Gulliver SB, Morissette SB. A Bayesian model averaging approach to examining changes in quality of life among returning Iraq and Afghanistan veterans. Int J Methods Psychiatr Res. 2014 Sep;23(3):345-58. doi: 10.1002/mpr.1442. Epub 2014 Jun 18. |
| 25158641 | Result | Grosso JA, Kimbrel NA, Dolan S, Meyer EC, Kruse MI, Gulliver SB, Morissette SB. A test of whether coping styles moderate the effect of PTSD symptoms on alcohol outcomes. J Trauma Stress. 2014 Aug;27(4):478-82. doi: 10.1002/jts.21943. |
| 25238984 | Result | Kimbrel NA, Evans LD, Patel AB, Wilson LC, Meyer EC, Gulliver SB, Morissette SB. The critical warzone experiences (CWE) scale: initial psychometric properties and association with PTSD, anxiety, and depression. Psychiatry Res. 2014 Dec 30;220(3):1118-24. doi: 10.1016/j.psychres.2014.08.053. Epub 2014 Sep 6. |
| 25314020 | Result | Kimbrel NA, Morissette SB, Meyer EC, Chrestman R, Jamroz R, Silvia PJ, Beckham JC, Young KA. Effect of the 5-HTTLPR polymorphism on posttraumatic stress disorder, depression, anxiety, and quality of life among Iraq and Afghanistan veterans. Anxiety Stress Coping. 2015;28(4):456-66. doi: 10.1080/10615806.2014.973862. Epub 2014 Nov 14. |
| 25534500 | Result | Wilson LC, Kimbrel NA, Meyer EC, Young KA, Morissette SB. Do child abuse and maternal care interact to predict military sexual trauma? J Clin Psychol. 2015 Apr;71(4):378-86. doi: 10.1002/jclp.22143. Epub 2014 Dec 22. |
| 25541538 | Result | Kimbrel NA, DeBeer BB, Meyer EC, Silvia PJ, Beckham JC, Young KA, Morissette SB. An examination of the broader effects of warzone experiences on returning Iraq/Afghanistan veterans' psychiatric health. Psychiatry Res. 2015 Mar 30;226(1):78-83. doi: 10.1016/j.psychres.2014.12.007. Epub 2014 Dec 13. |
| 25808565 | Result | Hiraoka R, Meyer EC, Kimbrel NA, DeBeer BB, Gulliver SB, Morissette SB. Self-Compassion as a prospective predictor of PTSD symptom severity among trauma-exposed U.S. Iraq and Afghanistan war veterans. J Trauma Stress. 2015 Apr;28(2):127-33. doi: 10.1002/jts.21995. Epub 2015 Mar 21. |
| 39509229 | Derived | Myers MN, Kurz AS, Paul J, Wild MG, O'Brien SF. Gender differences in reported potentially morally injurious events among post-9/11 U.S. combat veterans, using two measures. Psychol Trauma. 2025 Nov;17(8):1751-1761. doi: 10.1037/tra0001782. Epub 2024 Nov 7. |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
|
|
| Secondary | Inventory of Psychosocial Functioning (IPF) | 80-item self-report measure of psychosocial functioning across multiple domains (e.g., family, social, day-to-day activities). Items are rated on a 7-point scale ranging from 0 ("never") to 6 ("always"). Lower scores indicate more positive outcomes. | Sample sizes differ due to attrition and missing data. | Posted | Mean | Standard Deviation | score on a scale | one year |
|
|
|
| Secondary | Quality of Life Scale (QLS) | Quality of life measure of functioning scored on a 1 (delighted) to 7 (terrible) scale. Scores are summed with higher scores indicating lower quality of life. Total scores range from 16 - 112. | Sample sizes differ due to attrition and missing data. | Posted | Mean | Standard Deviation | score on a scale | one year |
|
|
|
| Secondary | Clinician Administered PTSD Scale (CAPS-5) | Total scores reflecting PTSD symptom severity. Scores ranging from 0-136 (higher score = more severe). | Sample sizes differ across time points due to attrition and missing data. | Posted | Mean | Standard Deviation | score on a scale | one year |
|
|
|
| 28 |
| 309 |
| 2 |
| 309 |
| hospitalized for homicidal ideation | Psychiatric disorders | Systematic Assessment |
|
| Hospitalized for mental health | Psychiatric disorders | Systematic Assessment |
|
| Hospitalized for physical condition | General disorders | Systematic Assessment |
|
| ER for physical condition | General disorders | Systematic Assessment |
|
| Detained in jail | Social circumstances | Systematic Assessment |
|
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| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
|
|
| 8 months |
|
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| 12 months |
|
|
|