Omega-3 and Aspirin in Periodontal Regeneration

The Effect of Host Response Modulation Therapy (Omega 3 Plus Low-dose Aspirin) as an Adjunctive Treatment of Chronic Periodontitis (Clinical and Biochemical Study)

To evaluate the efficacy of systemic administration of omega 3 PUFA plus low dose aspirin as an adjunctive therapy to regenerative modality of grade II furcation defects in periodontitis patients.

In this study, we tested the hypothesis that the administration of omega 3 PUFA plus low dose aspirin would augment the results following regenerative therapy of furcation defects in chronic periodontitis patients.

Inclusion Criteria:

• suffering moderate to sever chronic periodontitis and displaying at least a single grade II furcation defect according to Glickman's classification 1953, determined by both clinical and radiographic examinations;
• free from systemic diseases known to influence the periodontal condition and not receiving any medication known to affect the periodontal status;
• have not receive any periodontal therapy for a minimum of 6 months prior to the study.

Exclusion Criteria:

• Known hypersensitivity or allergy to one of the used medications
• Pregnancy or lactation
• Heavy smoking (more than 10cigarretes/day)
• History of alcohol abuse
• Participation in other clinical trials