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Background: Smoking reduces the effect of non-surgical periodontal therapy, a host modulation regimen consisting of omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation with low-dose aspirin (ASA) with or without systemic doxycycline has been proposed to improve treatment response.
The Aim of the study is to explore the clinical effects of orally administered omega-3 PUFA and ASA with or without systemic doxycycline with periodontal debridement in treatment of smoker individuals with stage III periodontitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Omega-3 PUFA and Aspirin | Experimental |
| |
| Omega-3 PUFA and Aspirin and doxycycline | Experimental |
| |
| Conventional | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omega-3 PUFA and Aspirin as adjunctive therapy to (SRP) | Other | fifteen patients will receive ω-3 PUFA + ASA (1g of fish oil/day + 75mg ASA/day for 2 months) after periodontal debridement (TG1) |
| Measure | Description | Time Frame |
|---|---|---|
| change in probing depth | the distance (in millimeters) from the gingival margin to the base of the gingival sulcus or periodontal pocket. | baseline (t0) and at 3 (t1) and 6 months (t2) |
| change in clinical attachment level | the distance (in millimeters) from the cemento-enamel junction (CEJ) to the base of the periodontal pocket. | baseline (t0) and at 3 (t1) and 6 months (t2) |
| Measure | Description | Time Frame |
|---|---|---|
| change in gingival index | score 0: Normal gingiva (pink, firm, no bleeding) score 1: Mild inflammation (Slight color change, Slight edema, No bleeding on probing) score 2:Moderate inflammation (Redness, edema, glazing, Bleeding on probing present) score 3: Severe inflammation (Marked redness and edema, Ulceration, Spontaneous bleeding) | baseline (t0) and at 3 (t1) and 6 months (t2) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt | Alexandria | Egypt |
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| Omega-3 PUFA and Aspirin and doxycycline as adjunctive therapy to (SRP) | Other | fifteen patients will receive ω-3 PUFA + ASA (1g of fish oil/day + 75mg ASA/day for 2 months) and oral dosage of doxycycline (100mg every 12 hours on day 1, then 100 mg once daily for 6 days) after periodontal debridement (TG2) |
|
| scaling and root planning (SRP) | Other | fifteen patients will receive periodontal debridement (CG) |
|
| change in bleeding on probing | presence of bleeding from the gingival sulcus or periodontal pocket within ~10 seconds after gentle probing. | baseline (t0) and at 3 (t1) and 6 months (t2) |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D004281 | Docosahexaenoic Acids |
| D001241 | Aspirin |
| D004318 | Doxycycline |
| D014080 | Tooth Exfoliation |
| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013754 | Tetracyclines |
| D009279 | Naphthacenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
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