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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-017794-37 | EudraCT Number |
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The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing morphine consumption and pain, and at the same time improving mobilisation after total knee arthroplasty.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adductor-Canal-Blockade | Experimental | Adductor-Canal-Blockade with ropivacaine |
|
| Adductor-Canal-blockade with saline | Placebo Comparator | Adductor-Canal-blockade with isotonic saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adductor-Canal-Blockade | Procedure | US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total morphine consumption | Total morphine consumption at the interval 0-24 hours postoperative. | 0-24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Total morphine consumption | Total morphine consumption at the intervals 0-2, 0-4, 0-8 and 0-26 hours postoperative. | 0-26 hours postoperative |
| Pain during rest | 0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pia Jæger, MD | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesia, Privathospitalet Hamlet, Frederiksberg, Denmark | Copenhagen | Frederiksberg | 2000 | Denmark | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22221014 | Derived | Jenstrup MT, Jaeger P, Lund J, Fomsgaard JS, Bache S, Mathiesen O, Larsen TK, Dahl JB. Effects of adductor-canal-blockade on pain and ambulation after total knee arthroplasty: a randomized study. Acta Anaesthesiol Scand. 2012 Mar;56(3):357-64. doi: 10.1111/j.1399-6576.2011.02621.x. Epub 2012 Jan 4. |
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| Adductor-Canal-blockade with saline | Procedure | US-guided Adductor-Canal-blockade with saline |
|
|
| 0-26 hours postoperative |
| Pain during 45 degrees active flexion of the knee | 0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative. | 0-26 hours postoperative |
| A change in pain in the placebo group | 0-100 mm at a visual analogue scale (VAS), at the intervals 24 and 26 hours postoperative. | 24-26 hours postoperative |
| Postoperative nausea | Nausea scores(0-3)at 2,4,8,24,26 hours postoperative. | 0-26 hours postoperative |
| Zofran consumption | Total zofran consumption at the intervals 0-24 and 24-26 hours postoperative. | 0-26 hours postoperative |
| Sedation | Seadtion score (0-3) at 2,4,8,24,26 hours postoperative. | 0-26 hours postoperative |
| Mobilisation | Number of seconds it takes to complete the "Timed Up and Go" test, at 20 and 26 hours postoperative. | 20-26 hours postoperative |
| Postoperative vomiting | Number of vomiting episodes at the intervals 0-2,2-4,4-8,8-24,24-26 hours postoperative. | 0-26 hours postoperative |
| Department of Surgery and Anaesthesia, Glostrup Hospital |
| Glostrup Municipality |
| Glostrup |
| 2600 |
| Denmark |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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