The purpose of this study was to investigate the association of inflammatory mediators found in the tear film during the development and following the induction of contact lens solution-induced corneal staining.

Inclusion Criteria:

For non-lens wearers:

• Normal eyes.
• Currently not wearing contact lenses and has not worn contact lenses for the previous 6 months.
• Free of dry eye using the Ocular Surface Disease Index (Schiffman et al).
• Other protocol-defined inclusion criteria may apply.

For contact lens wearers:

• Currently wearing soft contact lenses.
• Free of dry eye during lens wear using the Contact Lens Dry Eye Questionnaire Short-Form (Nichols et al, Cornea, 2002).
• Reports a contact lens wearing time of at least 12 hours per day, 7 days per week, daily wear basis (not overnight wear).
• Reports only occasional use of contact lens rewetting drops or artificial tears.
• Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

For non-lens wearers and contact lens wearers:

• Pregnant.
• Participating in another research study.
• Exhibiting staining with fluorescein in more than 5% of the total cornea (graded by "extent" of staining across 5 regions).
• Other protocol-defined exclusion criteria may apply.