Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers

Double-Blind, Randomized, Multiple-Dose, Placebo-Controlled, 2-Way Crossover Study To Study Effects of PF-04457845 On Polysomnographic Endpoints In Healthy Volunteers

PF-04457845 has been shown to temporarily decrease the dream (REM) period of sleep in rats, which suggests that PF-04457845 is active in rat's brains. This study is designed to see whether this is also the case in man.

Inclusion Criteria:

• Healthy male subjects between the ages of 18 and 55 years
• Body Mass Index (BMI) between 17.5 and 30.5 kg/m2
• Total body weight >50 kg

Exclusion Criteria:

• History of any active sleep disorder
• History of any sleep or circadian rhythm sleep disorder including RLS, narcolepsy, sleep apnea, phase advance or delay syndromes within the past 5 years
• Currently on or planning to be involved in night or rotating shift work or traveling across more than four time zones in 14 days prior to screening