Effect of Nocturnal Administration of Anti-hypertensive Medications in NoN-dippers

Effect of Nocturnal Administration of Anti-hypertensive Medications in NoN-dippers

The purpose of this study is to determine the effect of nocturnal administration of Anti-hypertensive medications in Non-dippers.

Efficacy variables.

1. ECHO
2. 24hr. horter
3. IMT
4. BUN/crea, urine analysis (microalbulinuria
5. Cardio vascular event. "

Inclusion Criteria:

1. Essential hypertension (stage 1-2)
2. 24hr. holer : non-dipper
3. Age 18 ~70.

Exclusion Criteria:

1. Any known malignant disease
2. Renal failure , creatinine >2.0mg/dl
3. Liver disease