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The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used for warts (verruca vulgaris).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liquid nitrogen and canthardin | Active Comparator | Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterwards. |
|
| Liquid nitrogen and placebo | Placebo Comparator | Liquid nitrogen applied to wart(s) then placebo vehicle afterwards. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liquid nitrogen and cantharidin | Drug | Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterward. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of common warts cleared | Percentage of treated warts cleared with treatment, as measured with dermatoscopic examination, after 12 weeks. | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Richard A Flygare, PhD | TUI University; North Idaho Dermatology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| North Idaho Dermatology | Coeur d'Alene | Idaho | 83814 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7857844 | Background | Berth-Jones J, Bourke J, Eglitis H, Harper C, Kirk P, Pavord S, Rajapakse R, Weston P, Wiggins T, Hutchinson PE. Value of a second freeze-thaw cycle in cryotherapy of common warts. Br J Dermatol. 1994 Dec;131(6):883-6. doi: 10.1111/j.1365-2133.1994.tb08594.x. | |
| 8089292 | Background | Guidelines of care for cryosurgery. American Academy of Dermatology Committee on Guidelines of Care. J Am Acad Dermatol. 1994 Oct;31(4):648-53. No abstract available. |
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| ID | Term |
|---|---|
| D014860 | Warts |
| ID | Term |
|---|---|
| D030361 | Papillomavirus Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D002193 | Cantharidin |
| ID | Term |
|---|---|
| D001572 | Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| Liquid nitrogen and topical placebo | Drug | Liquid nitrogen applied to wart(s), then placebo vehicle applied thereafter. |
|
| 11594862 | Background | Moed L, Shwayder TA, Chang MW. Cantharidin revisited: a blistering defense of an ancient medicine. Arch Dermatol. 2001 Oct;137(10):1357-60. doi: 10.1001/archderm.137.10.1357. |
| D017193 |
| Skin Diseases, Viral |
| D014412 | Tumor Virus Infections |
| D012874 | Skin Diseases, Infectious |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |