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| Name | Class |
|---|---|
| Ginsana SA | OTHER |
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DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated. Given that the brain relies on a constant supply of blood-borne metabolic substrates (e.g. glucose, oxygen), increasing regional cerebral blood flow may also have an impact on cognitive function. The current study aims to investigate the effects of two doses of DHA-rich fish oil on task-related cerebral hemodynamic response and cognitive performance in healthy adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 g DHA-rich fish oil | Active Comparator | 1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA plus 1 g olive oil |
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| 2 g DHA-rich fish oil | Active Comparator | 2 g DHA-rich fish oil containing 900 mg DHA + 180 mg EPA |
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| Placebo | Placebo Comparator | 2 g olive oil |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DHA-rich fish oil | Dietary Supplement | Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind. |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral blood flow | Cerebral blood flow will be assessed using Near Infrared Spectroscopy while participants complete a series of cognitive tasks. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function | Cognitive function will be assessed using a series of tasks that evaluate working memory, attention and executive function. | 12 weeks |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippa A Jackson | Northumbria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria University | Newcastle upon Tyne | Tyne and Wear | NE1 8ST | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22020134 | Derived | Jackson PA, Reay JL, Scholey AB, Kennedy DO. Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. Biol Psychol. 2012 Jan;89(1):183-90. doi: 10.1016/j.biopsycho.2011.10.006. Epub 2011 Oct 19. |
| Label | URL |
|---|---|
| Brain, Performance and Nutrition Research Centre, Northumbria University | View source |
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| Placebo | Dietary Supplement | 2 g placebo (olive oil) taken daily for 12 weeks |
|