Re-STOP DVT: Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users

Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users Undergoing Total Knee Replacement Arthroplasty: RE-STOP-DVT Study- A Prospective Randomized Controlled Trial

Reload of high dose statin may have potential for preventing deep vein thrombosis (DVT) in patients on statin undergoing total knee replacement arthroplasty.

A body of evidence have been reported that reloading of atorvastatin have efficacy in reducing periprocedural myocardial infarction and contrast induced nephropathy. These effects are considered to be mainly due to their antioxidant anti-thrombotic and anti-inflammatory property.

We, therefore, hypothesize that high dose atorvastatin re-loading may prevent DVT.

Inclusion Criteria:

• Patients who are going to receive total knee replacement arthroplasty from any cause.
• < 19 years old

Exclusion Criteria:

• patients with cancer
• Patients receiving anticoagulant agents from any cause
• current statin users
• expecting survival from other co-morbidity < 1year
• Bed ridden patient
• AST, ALT > 3times of upper normal limit
• CK> upper normal limit
• pregnancy
• patients who receives hormone replacement therapy