High-dose Periop Statins for Prevention of DVT

High-dose Statin Therapy in the Perioperative Period and DVT Prevention.

This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation when given in high doses in the perioperative period.

Inclusion Criteria:

• gynecologic tumor scheduled for resection

Exclusion Criteria:

• prior reaction to statins
• renal insufficiency
• liver disease
• h/o alcoholism
• prior h/o DVT or hypercoagulability
• concurrent medications that significantly affect cytochrome P450 3A4
• breast feeding or pregnancy