Peripheral Metabolic Effects of Somatostatin

Peripheral Metabolic Effects of Intra Arterial Somatostatin Infusion in Healthy Controls

The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled. The hypothesis is that Somatostatin infusion reverses insulin resistance caused by GH.

Inclusion Criteria:

• BMI < 27 kg/m2
• Written informed consent
• Healthy

Exclusion Criteria:

• Any disease
• Any use of medications
• Present or previous malignancy
• Alcohol dependency
• Allergy to trial medication