Per protocol intermediate analyses of 76 patients and enrollment difficulties.

The purpose of this study is to determine wether topical rapamycin is more efficient than topical steroids in the treatment of chronic erosive lichen planus.

Inclusion Criteria:

• Oral Lichen Planus
• Oral Erosive Area More Than 1cm²
• Lichen Planus Pathologically Proven

Exclusion Criteria:

• No Previous Treatment by Rapamycin
• Non Child Bearing Or Breast Feeding Woman
• Patient Who Cannot Be Treated By Rapamycin Or Betamethasone
• Chronic Renal Insufficiency (Creatinin Clearance < 40ml/Mn)
• Ongoing Treatment By Topical Calcineurin Inhibitors Or Systemic Steroids Or Retinoids Or Systemic Immunosuppressors Or Thalidomide Or Griseofulvin Or Antimalarials
• Cholesterolemia >7.8 Mmol/L Or Hypertriglyceridemia >3.95mmol/L Non Responsive To Medical Treatments
• Leucopenia (<3000/Mm3)
• Thrombopenia (<100 000/Mm3)
• Hypertransaminasemia (>3n)
• Hypersensitivity To Macrolides