The purpose of this study is to evaluate the safety and efficacy of 2% rebamipide compared to placebo in clearing of fluorescein staining of the central cornea in subjects with dry eye disease.

Inclusion Criteria:

• Age 18 years and older
• Diagnosis of dry eye as defined by the protocol
• Central corneal staining

Exclusion Criteria:

• Ongoing ocular disease that may interfere with study parameters
• Inability to stop using topical ophthalmic medications throughout the duration of the study
• Inability to stop the use of contact lenses for the duration of the study