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Patients with endometriosis-associated pain have conservative surgery performed to remove all visible lesions. Then, patients are randomized into two groups. In the first group patients have depot medroxyprogesterone acetate injections every 3 months for a total of 6 months.In the second group patients have oral contraceptive combined pills everyday for 6 months. Patients are followed up on recurrence of pain for 1 year after medication.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | Intramuscular depot medroxyprogesterone acetate |
|
| B | Active Comparator | ethinyl estradiol 30 micrograms combined with gestodene 75 micrograms |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intramuscular depot medroxyprogesterone acetate | Drug | 150 mg, Intramuscular, every 3 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patients' satisfaction with the treatment | 1 year and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| pain reduction and adverse side effects | 1 year and 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sopon Cheewadhanaraks, M.D. | Faculty of Medicine, Prince of Songkla University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Prince of Songkla University | Hat Yai | Changwat Songkhla | 90110 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12969698 | Background | Vercellini P, Frontino G, De Giorgi O, Pietropaolo G, Pasin R, Crosignani PG. Continuous use of an oral contraceptive for endometriosis-associated recurrent dysmenorrhea that does not respond to a cyclic pill regimen. Fertil Steril. 2003 Sep;80(3):560-3. doi: 10.1016/s0015-0282(03)00794-5. |
| Label | URL |
|---|---|
| Faculty of Medicine, Prince of Songkla University | View source |
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| ethinyl estradiol 30 micrograms, gestodene 75 micrograms | Drug | one tablet orally, everyday |
|
|
| ID | Term |
|---|---|
| D004715 | Endometriosis |
| D017699 | Pelvic Pain |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D017258 | Medroxyprogesterone Acetate |
| ID | Term |
|---|---|
| D008525 | Medroxyprogesterone |
| D006908 | Hydroxyprogesterones |
| D011374 | Progesterone |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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