This is a placebo-controlled, crossover study investigating the pharmacokinetic bioavailability of avenanthramides from avenanthramide-enriched oats and their in vivo metabolites in a cohort of healthy, older adults.

Inclusion Criteria:

• Men and postmenopausal women
• BMI 18.5-29.9 kg/m2

Exclusion Criteria:

• Cigarette smoking and/or nicotine replacement use
• Use of cholesterol-lowering medications
• Use of blood pressure-lowering medications
• Use of any stomach acid-lowering medications
• Cardiovascular (heart) disease
• Gastrointestinal disease
• Kidney disease
• Endocrine disease: including diabetes, untreated thyroid disease
• Rheumatoid arthritis
• Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
• Systolic blood pressure > 150 mm Hg and/or diastolic blood pressure > 95 mm Hg
• Regular use of oral steroids
• Regular daily intake of 2 or more alcoholic drinks
• Illicit drug use
• No fish oil supplements (including cod liver oil) for one month prior to study admission
• No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission