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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-018403-29 | EudraCT Number |
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The purpose of this study is to determine whether Transversus abdominis plane block is superior to placebo or superior to local infiltration in analgesic efficacy after groin hernia repair.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | TAP block with 25 ml of saline Ilioinguinal block with 10 ml of saline and local infiltration with 40 ml of saline. |
|
| Local infiltration | Active Comparator | Ilioinguinal block with 10 ml of ropivacaine 0,375% Local infiltration with 40 ml of ropivacaine 0,375% Tap block with 25 ml of saline |
|
| Transversus abdominis plane block | Experimental | 25 ml of Ropivacaine 0,75%, Ilioinguinal block with 10 ml saline and local infiltration with 40 ml of saline. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transversus abdominis plane block | Procedure | UL-guided TAP block with 25 ml of ropivacaine 0,75% unilateral, single dose, ilioinguinal block with 10 ml of saline and local infiltration with 40 ml of saline |
| Measure | Description | Time Frame |
|---|---|---|
| Pain scores by coughing between TAP block group and placebo group | Area under the curve (AUC)-pain during cough based on measurements at 0,2,4,6,8,19,24 hours postoperative | 0,2,4,6,8,19 and 24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Pain scores by coughing between placebo and local infiltration and between TAP block and local infiltration. | Area under the curve (AUC)-pain during cough based on measurements 0,2,4,6,8,19,24 hours postoperative. | 0,2,4,6,8,19 and 24 hours postoperative |
| Total opioid consumption |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pernille L Petersen, MD | Glostrup University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology, Glostrup university hospital | Glostrup Municipality | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23549122 | Derived | Petersen PL, Mathiesen O, Stjernholm P, Kristiansen VB, Torup H, Hansen EG, Mitchell AU, Moeller A, Rosenberg J, Dahl JB. The effect of transversus abdominis plane block or local anaesthetic infiltration in inguinal hernia repair: a randomised clinical trial. Eur J Anaesthesiol. 2013 Jul;30(7):415-21. doi: 10.1097/EJA.0b013e32835fc86f. |
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| ID | Term |
|---|---|
| D006547 | Hernia |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D000772 | Anesthesia, Local |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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|
| Saline | Procedure | UL-guided Tap block with 25 ml of saline single dose Ilioinguinal block with 10 ml of saline and local infiltration with saline 40 ml single dose |
|
|
| Local infiltration | Procedure | Ilioinguinal block with 10 ml of ropivacaine 0,375% single dose, local infiltration with 40 ml of ropivacaine 0,375% single dose, UL-guided Tap block with 25 ml of saline single dose |
|
|
Total morphine consumption 0-2 hours postoperative. Total ketobemidone consumption 2-24 hours postoperative. |
| 0-24 hours postoperative |
| Postoperative nausea and vomiting | Levels of nausea (0-3)at 0,2,4,6,8,19,24 hours postoperative Number of vomits 0-2, 2-4, 4-6, 6-8, 8-19 og 19-24 hours postoperative. | 0,2,4,6,8,19,24 hours postoperative |
| Sedation | Levels of sedation (0-3)at 0,2,4,6,8,19,24 hours postoperative. | 0,2,4,6,8,19,24 hours postoperative |
| Pain scores at rest between TAP block versus placebo and TAP block versus infiltration and infiltration versus placebo | Area under the curve (AUC)-pain at rest based on measurements at 0,2,4,6,8,19,24 hours postoperative | 0,2,4,6,8,19,24 hours postoperative |
| D017670 |
| Sodium Compounds |
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |