An Observational Study of CPT-11 Based Regimens and UGT1A1 Genotypes in Metastatic Colorectal Cancer (mCRC)

A Prospective Observational Study of the Efficacy and Safety of CPT-11 Based Regimens for UGT1A1 Genotype Guided Patients With Metastatic Colorectal Cancer

The purpose of this study is to examine the correlation between UGT1A1 genotypes and the efficacy of CPT-11 based regimens (FOLFIRI, CPT-11+S-1, CPT-11) for patients with metastatic colorectal cancer.

Inclusion Criteria:

• Metastatic colorectal cancer (adenocarcinoma)
• UGT1A1 genotyped patients
• Patients to receiving FOLFIRI, CPT-11+S-1 and CPT-11 alone therapy (with or without molecular targeted agents)

Exclusion Criteria:

• Contraindication of CPT-11
• Eastern Cooperative Oncology Group (ECOG) Performance Score (PS) 3-4
• Patients to receiving CPT-11 as adjuvant chemotherapy
• History of pelvic irradiation